High-sensitive and disposable myocardial infarction biomarker immunosensor with optofluidic microtubule lasing
نویسندگان
چکیده
Abstract The early diagnosis of myocardial infarction can significantly improve the survival rate in emergency treatment, which is mainly implemented by immunoassay for biomarkers such as cardiac troponins blood. In this work, a disposable optofluidic microtubule whispering gallery mode (WGM) immunosensor label-free troponin I-C (cTnI-C) complex detection has been proposed and demonstrated with active interrogation enhancement. simply fabricated silica capillary pressurized tapering technology thin-wall, cTnI antibodies are immobilized on inner wall surface through self-adherent polydopamine substrate. By configuring two coupling microfibers, double-fiber-coupled cavity serve tunable filter mutual-coupled polarimetric fiber ring laser (FRL), whose output wavelength determined cTnI-C concentration inherent microfluidic channel. Due to cyclic-cumulative gain FRL, characteristic resonant peak optical sensing signal enhanced spectral width compression signal-to-noise ratio improvement, therefore be achieved tracking FRL conveniently. dynamic binding unbinding process antigen–antibody illustrated monitoring lasing continuously. Our all-fiber here advantages fast detection, real-time monitor, high sensitivity element, an innovative detecting tool infarction.
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ژورنال
عنوان ژورنال: Nanophotonics
سال: 2022
ISSN: ['2192-8606', '2192-8614']
DOI: https://doi.org/10.1515/nanoph-2022-0208